RPSC Senior Scientific Officer Syllabus 2021 PDF – Download Exam Pattern Here!!!!

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RPSC Senior Scientific Officer Syllabus 2021 PDF – Download Exam Pattern Here!!!! Rajasthan Public Service Commission has uploaded the Exam Pattern & Syllabus for Senior Scientific Officer for Various Divisions. Candidates can download the Rajasthan PSC Senior Scientific Officer Post Syllabus from our examsdaily.in website. Stay Connected with us for further updates

RPSC Syllabus 2021:

Name of the Board

Rajasthan Public Service Commission
Name of the Post

Senior Scientific Officer

Exam Date

Announce Soon
Status

Syllabus Available

RPSC SSO Selection Process:

The Selection process and criteria for Rajasthan PSC Senior Scientific Officer Recruitment 2021 is Short List and Interview Process. 

Latest Government Job Notification 2021

RPSC Senior Scientific Officer Exam Pattern :

Name of The Subjects

Questions

Marks

Time Duration

Concerned Subjects

100

100

2 Hrs

Graduate Jobs 2021

RPSC SSO Syllabus :

For the sake of the candidates who are appeared for the Written Exam conducted by the officials of the Rajasthan PSC Department, we had projected the PDF of the Rajasthan PSC Senior Scientific Officer Syllabus 2021. Also, the point wise and subject wise syllabus topics are arranged here in the below section. Go through them and accordingly prepare a schedule as well.

Senior Scientific Officer – Photo Division:

UNIT-I:

Elementary geometrical optics in the paraxial approximation. Refractive index; reflection and refraction at a plane boundary from Huygens’ principle and Fermat’s principle; Snell’s Law; total internal reflection. Image formation by reflection at a spherical boundary; concave and convex mirrors. Real and virtual images. Magnification.

UNIT-II:

Image formation by refraction at a spherical boundary and by converging and diverging thin lenses. Derivation of the expression for the focal length of a thin lens. Non- xaminable: Image formation by systems of thin lenses or mirrors as illustrated by: a simple astronomical telescope consisting of two convex lenses, a simple reflecting telescope, a simple microscope.

UNIT-III:

Simple two-slit interference (restricted to slits of negligible width). The diffraction grating, its experimental arrangement; conditions for proper illumination. The dispersion of a diffraction grating. (The multiple-slit interference pattern and the resolution of a diffraction grating are excluded.) Fraunhofer diffraction by a single slit. The resolution of a simple lens.

UNIT-IV:

Oscillations, simple harmonic motion, damped harmonic motion, forced oscillation and resonance. Wave equation, harmonic solutions, plane and spherical waves, superposition of waves, beats, stationary waves Doppler’s Effect, phase and group velocities. Conditions of interference, Newton’s rings and Michelson’s interferometer. Diffraction-Fresnel and Fraunhofer, diffraction by plain transmission grating, Rayleigh criterion, resolving power of grating and telescope.

UNIT-V:

Black body radiations, De Borglie waves. Photo-electric effect, Compton effect, wave-particle duality, Uncertainty principle and its applications (like – size of H-atom, zero point energy, wave packet, finite width of energy levels).

UNIT-VI

Basics of Light sources, Mirrors, lens, Focal length, Image formation, Newton’s laws on motion, Callers’ law, Bernuli principals, Doppler’s Principal and effects.

UNIT-VII:

Photographic Optics and Equipments: History of B/W Photography: Early experiments and later developments. Photographic, Chromatic and spherical aberration, curvature of field, distortion and astigmatism, methods of reducing the above defects. Aperture of diaphragm, its function, f notation, different kinds of aperture and their construction, dependence of depth of field and focus on distance and f number. Types of camera lenses: Single (meniscus), achromatic, symmetrical and unsymmetrical lenses, telephoto, zoom, macro, supplimentry and fish-eye lenses.

UNIT-VIII:

Concept of Digital imaging, Concept of the megapixels, optical and digital zoom, image size, file size, concept of frame, perception and composition. Photographic camera types: Pin-hole, box, folding, large and medium format cameras, single lens reflex (SLR) and twin lens reflex (TLR), miniature, subminiature and instant camera, choice of camera and sizes, rising, falling, cross movements and swing back devices. Principal parts of Photographic cameras: (a) Lens (b) Aperture (c) Shutters, various types and their functions, focal plane shutter and in-between the lens shutter, shutter synchronization self-timer. View-finders and focusing systems: Direct vision and ground glass view finders, frame view finder, plane
mirror and penta-prism view-finder, fresnel prism focusing, split image focusing, range finders and range finder focusing , mechanism focusing distance scale. Film chamber: Exposure counter, self-timer, tripod stand, panning tilt head, lens hood, cable release.

UNIT-IX:

Photographic Light Sources: (a) Natural source, the Sun, nature and intensity of the sunlight at different times of the day, different weather conditions. (b) Artificial light sources: nature, intensity of different types of light sources used in photography namely.

UNIT-X:

Printing: Contact printing, projection printing using an enlarger, enlargement on Bromide paper, selection of papers, technique of enlargement – Burning, dodging, vignetting, flashing, diffusion or soft focus, distortion creation and correction, making cartoon and multiple photograph on the same paper, making giant enlargements, glazing and drying. Trick Photography: Methods, effect box, photomontage, wire screen-star effect, use of diffraction grating, texture effect, photolith, Bas-relief, solarization and photo grams. Photomicrography: Photography using a microscope, essential equipments and methods, use of polarized light. Colour Photography: Basic principle, idea of colour, primary and secondary colours, colour and colour temperature.

Download Syllabus for Senior Scientific Officer (Photo Division) PDF

Senior Scientific Officer – Narcotics Division:

Unit I:

Analytical Chemistry: Classification of analytical methods – Classical and Instrumental, volumetric, titrimetric and gravimetric techniques, selection of proper analytical techniques: types and range of determination, accuracy, precision and errors, sample preparation, handling of reagents with safety, density and viscosity measurements. Statistical Analysis: Mean, Mode, Median, Correlation and Regression analysis, Null Hypothesis, Variance, t-test, Chi-Square test. Type of Data, Measure of central tendency, Dispersion of Data, Correlation, Probability and Proof.

Unit II:

Analysis of unknown samples :- Organic: Physical examination, element detection (N, S, Cl, Br, I, F), Functional Group analysis (-OH, -COOH, -NO2, -NH2, -CONH2, -CO-, -CHO, Hydrocarbons) Inorganic: Qualitative analysis of cations and anions with special reference to cations i.e. As, Sb, Pb, Ba, Cu, Hg, Zn and Tl and anions i.e.NO2- , NO3- ,S2- , SO4 2- , SO3 2- , halides and cyanides. Analysis of poisonous gases: CO, H2S, PH3, CH4 and NH3.

Unit III

Spectroscopic and other techniques :- Unifying principles : Electromagnetic radiation, interaction of electromagnetic radiation with matter- absorption, emission, transmission, reflection, refraction, dispersion, polarization and scattering. Basic principles, instrumentation and applications: UV- Visible, FTIR, AAS, Mass, Spectroscopy, Fluorescence and Phosphorescence spectrophotometry, ESR Spectroscopy. Fundamentals of Acids, Bases and Buffers, pH, pKa , and pKb values, principles, instrumentation and applications of pH metry, Potentiometry, Conductometry and Microscopic analysis in forensic Science.

Unit IV:

Chromatography and Electrophoresis : General Principles and types of chromatographic techniques: Paper chromatography, column chromatography, Thin layer chromatography, adsorption chromatography, partition chromatography, Gas chromatography, Gas-liquid
chromatography, Ion exchange chromatography, Exclusion (permeation) chromatography, affinity chromatography, HPLC, HPTLC, Capillary Chromatography and Electrophoresis.

Unit V:

Basic Organic Chemistry: Important preparations and properties of alkanes, alkenes, alkynes, aromatic hydrocarbons, alcohols, phenols, carboxylic acids, aldehydes, ketones, amines and nitro compounds.

Unit VI:

Proteins: Classification, Structure and Properties, Molecular weight determination, Isoelectric point, coagulation and denaturation. Carbohydrates: Classification, Structure and Reactions. Fats and Lipids: Classification, Structure and Reactions. Alkaloids: Classification, Isolation and Identification.

Unit VII:

Extraction, isolation & identification of Alkaloids viz- Morphine, Codeine, Brucine, Strychnine, Nicotine, Atropine, Hyoscyamine, Cocaine, Heroin and Dhatura alkaloids. Extraction, isolation & identification of sedative, depressants, stimulants, opiates and drugs of abuse.

Unit VIII:

Medicinal Chemistry: General drugs, Designer Drugs, Drugs of abuse, mode of administration and pharmacological action of drugs of forensic importance. Drugs Act, Excise Act and NDPS Act.

Unit IX:

Narcotics drugs and psychotropic substances: Definition, types, appearance, production and chemical characteristics. Common terminology of various drugs. Drug action on central nervous system. Sampling and analytical techniques for qualitative & quantitative analysis.

Unit X:

Plants of Narcotic importance and their morphology: Papaver somniferum, Cannabis sativa, Coca plant and analysis of their active constituents. Psychotropic substances: Amphetamines, Benzodiazepines and their derivatives. Barbiturates, Lysergides, Mascalines and Psilocybin etc.

Download Syllabus for Senior Scientific Officer (Narcotics Division) PDF

Senior Scientific Officer Toxicology Divison:

Unit-I:

Analytical Chemistry : Classification of analytical methods – Classical and Instrumental, volumetric, titrimetric and gravimetric techniques, selection of proper analytical techniques: types and range of determination, accuracy, precision and errors, sample preparation, handling of reagents with safety, density and viscosity measurements. Statistical analysis : Mean, Mode, Median, Correlation and Regression analysis, Null Hypothesis, Variance, t-test, Chi-Square test. Type of Data, Measure of central tendency, Dispersion of data, Correlation, Probability and Proof.

Unit-II:

Analysis of unknown samples:- Organic: Physical examination, element detection (N, S, Cl, Br, I, F), Functional Group analysis (-OH, -COOH, -NO2, -NH2, -CONH2, -CO-, -CHO, Hydrocarbons) Inorganic: Qualitative analysis of cations and anions with special reference to cations i.e. As, Sb, Pb, Ba, Cu, Hg, Zn and Tl and anions i.e.NO2-, NO3 ,S2-, SO42-, SO32- , halides and cyanides. Analysis of poisonous gases: CO, H2S, PH3, CH4 and NH3.

Unit-III:

Spectroscopic and other techniques:-
Unifying principles : Electromagnetic radiation, interaction of electromagnetic radiation with matter- absorption, emission, transmission, reflection, refraction, dispersion, polarization and scattering. Basic principles, instrumentation and applications: UV- Visible, FTIR, AAS, Mass, Spectroscopy, Fluorescence and Phosphorescence spectrophotometry, ESR. Fundamentals of Acids, Bases and Buffers, pH, pKa , and pKb values, principles, instrumentation and applications of pH metry, Potentiometry, Conductometry and Microscopic analysis in forensic science.

Unit-IV:

Chromatography and Electrophoresis: General Principles and types of chromatographic techniques: Paper chromatography, column chromatography, Thin layer chromatography, adsorption chromatography, partition chromatography, Gas chromatography, Gas-liquid chromatography, Ion exchange chromatography, Exclusion (permeation) chromatography, affinity chromatography, HPLC, HPTLC, Capillary Chromatography and Electrophoresis.

Unit-V:

Basic Organic Chemistry: Important preparations and properties of alkanes, alkenes, alkynes, aromatic hydrocarbons, alcohols, phenols, carboxylic acids, aldehydes, ketones, amines and nitro compounds.

Unit-VI:

Proteins: Classification, Structure and Properties, Molecular weight determination, Isoelectric point, coagulation and denaturation. Carbohydrates: Classification, Structure and Reactions. Fats and Lipids: Classification, Structure and Reactions. Alkaloids: Classification, Isolation and Identification.

Unit-VII:

Forensic Toxicological examination and significance, Poison : Definition, classification, mode of action, chemical nature, methods of poison administration, Classification of poisoning : Accidental, homicidal and suicidal. Symptoms of poisoning and antidotes, Collection and preservation of toxicological exhibits in poisoning cases. Postmortem examination and postmortem changes, Medicolegal aspects of wounds, Modes of death.

Unit-VIII:

Different methods of extraction and isolation of poisons from visceral organs and other biological specimens : Solvent extraction, distillation/steam distillation, micro diffusion, dialysis, dry ashing and wet digestion.

Pharmacolgy : Metabolism and excretion of poisons – Introduction, pathways of drug metabolism, nonsynthetic and synthetic pathways like oxidation, hydroxylation, N-and O-dealkylation, sulphoxide formation, conjugation, acetylation, methylation of drugs/poisons as exemplified by alcohols, aldehydes, ketones, aliphatic amines, phenols, cyanide, barbiturates, opiates, benzodiazepines and amphetamines.

Unit-IX:

Analysis of volatile poisons, toxic metals and non-metallic anions in biological  fluids. Analysis of pesticides : Organochlorinated, Organophosphorus, Synthetic pyrethroids, Carbamates, Aluminium phosphide and Zinc phosphide in visceral tissues.

Unit-X:

Methods of analysis of acidic and neutral drugs in biological fluids, salicylic acid, benzoic acid, aspirin, meprobamate, barbiturates etc. Method of analysis of basic drugs of abuse from biological specimens : Opium and its alkaloids, atropine, strychnine, brucine, cocaine, amphetamines and its derivatives, benzodiazepines, LSD, ketamine, methaqualone and nicotine. Method of analysis of mechanical poisons- Glass, diamond and hair. Plant poisons and their examination : Dhatura, Atropa belladonna, Marking nut, Nux vomica, Oleander, Aconite, Abrus, Cannabis, Croton and poisonous fungi.

Download Syllabus for Senior Scientific Officer (Toxicology Division) PDF

Senior Scientific Officer – Serology Division:

UNIT-I:

CELL STRUCTURE, MOLECULES AND THEIR INTERACTION: Structural organization and functions of cell including Plasma membrane, intracellular organelles (Nucleus, Mitochondria, Golgi-bodies, Lysosomes, Endoplasmic reticulum, Peroxysomes) and types and structure of Chromosomes, Cell division and cell cycle.

Bio-molecules-Structure, composition and function (carbohydrates, lipids, proteins and nucleic acids), pH, buffer and buffer system, Enzymes- types and their functions, regulation, enzyme inhibition, iso-enzymes. Nucleic acids, their structure and functions, types of DNA and RNA, replication mechanism, Proteins synthesis.

UNIT-II:

HUMAN ANATOMY AND PHYSIOLOGY: Tissues of body, epithelia and glands, their classification and functions, connective tissues, cartilage- structure and types, bones- formation, gross structure, fracture and healing, Structure and growth of teeth, types, dentition-pattern and formula, eruption sequence and age determination, dental anomalies and their significance in personal identification, bite marks of human/ animals and their analysis. Structure and functions of major organ systems and their physiology Integumentary, digestive, skeleton, respiratory, endocrine, nervous, cardiovascular, excretory, reproductive, muscular and neuromuscular systems, blood physiology.

UNIT-III

ECOLOGY, ENVIRONMENT AND MICROBIOLOGY: Ecosystem and their types, ecological factors, types of pollution, types of waste, BOD, COD, effect on human health, algal blooms and identification and composition, eutrophication and their effects. Various types of planktons, diatoms, preparation and identification and their forensic importance. Diatom tests and its importance in drowning cases, precaution in collection, preservation and forwarding of biological samples for diatom test, methods of isolation of diatoms from different body tissues/bone marrow and water samples. Soil and water analysis for various microbes, isolation, classification, cell structure of bacteria and fungi, spores, microbes of soil and spoiled food.

UNIT IV:

BIOSYSTEMATICS, TAXONOMY, ANIMAL CLASSIFICATION AND GENETICS: Chemotaxonomy, Cytotaxonomy, Molecular Taxonomy and General classification of Animals (classification of Invertebrates upto order, classification of chordates upto class) Mendelian and Non mendelian inheritance, linkage, recombination and crossing over, chromosomal basis of inheritance, sex linked inheritance,
chromosomal aberration, Eugenics.

UNIT V:

TOOLS AND TECHNIQUES IN BIOLOGY: Tissue preparation- fixation, preparation of paraffin and plastic blocks, sectioningrotary microtome, cryostat, vibratome and ultrathin sectioning. Staining- various staining techniques- simple and double staining, histochemical staining for bio molecules, Decalcification of bones and tooth, immunocytochemical staining. Chromatographic techniques- Paper, TLC, GLC, HPLC, GCMS, Electrophoresisgel, agar, SDS and rocket; Statistical analysis- data collection and processing, regression and correlation, ANOVA analysis, probability, t-test, p value, x2 test (Chi square).

UNIT- VI:

FORENSIC TECHNIQUES: ANTHROPOLOGY: Anatomical description of skeletons of human and animals as relevant to forensics, ossification and identification of bones for determination of age, sex, race, stature etc. forensic anthropometry/ osteometry and tools involved. Determination of personal identity- sex differences in skull, pelvis and other bones. Calculation of stature from long bones, identification of burnt bones. Recovery of
and identification of skeletal remains in accident, crimes and mass disasters, recovery, packing and storage of fleshed and burnt bone remains of human/ animal of forensic importance. Skeletal pathology and trauma of bones, facial reconstruction and superimposition, craniofacial superimposition techniques as photographic and video superimposition.

UNIT-VII:

PHYSICAL EVIDENCE COLLECTION & PACKAGING OF EXHIBITS FROM CRIME SCENE: Physical evidence, types and importance in a criminal investigation, Protecting a
scene of crime – various steps involved, contamination issues. Reconstructing of crime scene, Protection of Packaging & transportation Biological Evidences their documentation and Chain of Custody Legal and court procedure pertaining to expert testimony, admissibility of scientific evidence under 293 CrPC.

MICROSCOPY AND ITS APPLICATION :
Basic principles and working of simple, Compound, Comparison, Phase-contrast, stereo-zoom, Polarizing, Fluorescence, confocal microscopy, Scanning electron and transmission electron microscope, colorimeter analysis and UV light source. Spectroscopy: Principle and significance of UV-Vis spectroscopy, Fluorescence spectroscopy, FRET, Luminescence, Circular Dichroism, Infra-Red spectroscopy, Raman spectroscopy, Nuclear Magnetic Resonance, X-ray diffraction, Mass spectrometry.

UNIT-VIII:

EXAMINATION OF BODY FLUIDS & THEIR STAINS: Introduction to various types of body fluids, Composition, Physical pattern and Identification of seminal stains: Occurence and significance. Species Determination. Age of semen stain. Detailed Laboratory examination of semen stain. Polymorphic Enzymes in semen and their significance. D.N.A. typing of semen sample. Examination of Saliva, Urine, Perspiration and other physiological
fluids presumptive tests (U.V. test, Florence test, Spermine (Barberio) test, Choline test, Acid phosphatase test) and confirmatory test including Azoospermic semen stain (p-30, Prostate-specific antigen or PSA, Microscopic examination), Morphological structure of spermatozoa of human and animals, Identification of lochial and menstrual blood stains by microscopic, biochemical and immuno-electrophoretic method, Identification and examination of other body fluids/stains–vaginal, saliva, urine, faeces, vomit etc., Secretor and non –secretor. Identification and examination of body tissues of human/animal.

IMMUNOLOGICAL TEST: Presumptive & Confirmatory Tests for blood and origin. Application of immunological techniques in forensic serology Determination of species by
precipitin test (diffusion method) and Gelelectrophoresis. Innate and Adaptive immunity, B cell /T cell –structure, development, diversity and recognition. Antigen and Antibodies – structure, types and function of antibody, monoclonal antibodies, antigen, hapten, adjuvants, antigen-antibody interaction and their application. Blood groups- ABO, MN, Rh polymorphic blood groups, Application of ABO blood group in disputed paternity cases, polymorphic enzymes and polymorphic proteins in the reference of forensic serology. HLA antigen. Secretor and non secretor status. Blood grouping in biological fluids other than blood. Determination of ABO blood group by absorption inhibition, absorption elution
and mixed agglutination method.

UNIT-IX:

FORENSIC GENETICS AND ROLE OF DNA FINGERPRINTING: History of DNA fingerprinting, utility of DNA fingerprinting in crime investigation in parentage dispute, wild life, veterinary and agriculture etc., Legal and Ethical issues. Collection, preservation and transport of samples viz, semen, saliva, hair, bone, flesh etc for DNA profiling, DNA methodology for isolation, typing, interpretation of results, STR analysis, polymerase chain reaction, types and it’s application, mitochondrial analysis, determination of sex & species and racial origin. Analytical techniques: Chromatography, Gel filtration, Ion exchange and affinity chromatography, Electrophoresis, SDS-PAGE, AGE, PFGE, Southern, Northern and Western blotting, ELISA, DNA foot printing, PCR, Asymmetric PCR, methylation-specific PCR, Nested PCR, Inverse PCR, reverse transcriptase PCR, Real-time-PCR, Protein sequencing methods, DNA sequencing methods, Next Generation Sequencing RFLP maps, RAPD markers, AFLP markers, SNP analysis.

UNIT-X:

WILD LIFE FORENSICS:
Wild life, Importance of protected and endangered species of Animals. National and International scenario of wild life, Sanctuaries and National parks. Relevant provision of wild life and environmental act. Types of wildlife crimes, different methods of poaching of wildlife animals, Illegal Trade of wildlife material, Identification and examination of different kinds of wildlife crime exhibits. Examination of fabricated hides, ivory, nail etc. Identification of Wild life and domestic animal.

FORENSIC ENTOMOLOGY:
Introduction, History, Significance, Classification and Biology of insects and other arthropods, Life cycle and forensic application of insects, Importance of some bacteria, Micro Organism and Insects in Forensic Science. Determination of time since death (postmortem interval i.e. PMI) – Dipterans larval development & succession on carrion and its relationship to determine time of death, impact of ecological factors on insects developments, rearing insects & calculating PMI, identification of larval instars, determining whether the body has been moved, linking suspect to the scene, Forensic Entomo-toxicology- identification of drugs and toxins from the insects and larvae feeding on the body, collection and preservation of entomological evidence at a crime scene.

HISTOLOGICAL AND ANATOMICAL EXAMINATION OF SOME PLANTS YIELDING DRUG: Morphology and anatomy of plants, types of plants yielding drugs of abuse – opium, cannabis, coca, tobacco. Identification of plants of Cannabis sativa (Ganja & bhang), opium (Papaver somniferum), tobacco (Nicotiana tabacum) etc. in criminal cases.

SEROLOGY DIVISION (M.Sc. BIO-CHEMISTRY)

UNIT-I:

Foundation of Biochemistry: Cellular and chemical foundations of life, Water: unique properties, weak interactions in aqueous systems, ionization of water, buffering action in biological system.

Carbohydrate chemistry: Structure of classification of monosaccharides, disaccharides, and polysaccharides, Glycolytic pathway, TCA cycle, pentose phosphate pathways, glycogen metabolism.

Lipid Chemistry: Building blocks of lipids – fatty acids, glycerol, ceramide; Structural lipids in membranes – glycerophospholipids; sphingolipids and sterols; Composition and synthesis of lipoproteins and transportation, oxidation of fatty acids, biosynthesis of lipids, cholesterol metabolism.

Protein Chemistry: Structure and classification of amino acids, peptide, polypeptide, Ramachandran plot, protein folding, Primary, Secondary, Tertiary and Quaternary structure of proteins; essential, non-essential and non-standard amino acids.

Nucleic acid chemistry: Structure of purine, pyrimidine, nucleoside & nucleotides, De-Novo synthesis of purine and pyrimidine, Synthesis of nucleoside di- and triphosphates, deoxynucleotides, degradation of purine and pyrimidine nucleotides, salvage pathways of nucleotides synthesis, different types of DNA and RNA, Watson-Crick model of DNA, Structure of mRNA, tRNA and rRNA.

UNIT-II:

Enzyme chemistry: Enzyme definition, basic principle of enzyme action, activation energy, General characteristics of enzymes; nature of enzymes – protein and non-protein (ribozymes – RNaseP, abzymes), apoenzyme, holoenzyme. Fischer’s lock and key hypothesis, nomenclature and classification of enzymes, mechanisms of action various enzymes including chymotrypsin, lysozyme. Enzyme kinetics: Kinetics of single substrate reaction, Michaelis-Menten equation, Lineweaver-Burk plot, Eadie-Hofstee and Hanes plot. Determination of KM and Vmax, Kcat, specificity constant.Enzyme Inhibition: Reversible and irreversible inhibition, kinetics of bi-substrate reaction. Enzyme regulation: Allosteric enzymes, symmetrical and sequential model, Hill’s coefficients, cooperativity, Enzyme regulation and feedback control, enzyme activity regulation by post translational modification.

UNIT-III:

Classical genetics: Mendelian and non-Mendelian inheritance, genetic linkage, recombination and crossing over, chromosomal basis of inheritance, mutagenesis,genetic basis of sex determination, extra-nuclear inheritance.

Molecular Genetics: Structure of chromatin and chromosomes, Central dogma of molecular biology, replication, transcription, translation, regulation of geneexpression: transcriptional, translational and post-translational.

Cell Biology: Membrane models, chemical composition of membrane, membrane proteins, endocytosis, phagocytosis, liposomes and its application.

Structure and functions of intracellular organelles such as nucleus, mitochondria, endoplasmic reticulum, golgi apparatus, lysosomes, plastids, peroxisomes.

UNIT-IV:

Basic concept of development: Basic features of development in animals, gametogenesis, types of eggs, fertilization, cleavage, and blastula, modification of development in evolution, generation of multicellular embryo, formation of germ layers, patterning of vertebrate body plan.

Reproductive Biology: Reproductive strategies and reproductive cycles in vertebrates, spermatogenesis, oogenesis, hormonal regulation in gametogenesis in male and female, In-vitro fertilization, embryo transfer technology.

Nervous System: Organization of nervous system, somatic nervous system; sympathetic and parasympathetic system; structure and function of neuron and glial cells.
Musculo-skeletal System: Bone structure and function; smooth, cardiac and skeleton muscles, muscle contraction.

Endocrinology: Endocrine glands including pituitary, thyroid,etc; hormones, regulation of hormone secretion, peptide hormones and steroid hormones, biochemistry of hormone action.

Immunity: innate and acquired immunity, antibody, major histocompatibility complex, complement systems, T and B-cell maturation and differentiation, antigen processing and presentation, hypersensitive reaction and autoimmune diseases, polyclonal and monoclonal antibodies.

UNIT-V:

Blood: Components & functions of blood, lymph, CSF; Plasma and serum, major plasma proteins, Erythrocytes, Leukocytes, Platelets- structure and function; role of platelets in coagulation, Biochemical mechanism of blood clotting and fibrinolytic system.

Glycogen storage diseases: Von Gierke, Pompe, Cori and McArdle. Anemia and amino acid metabolism: Hemophilia and thrombosis, Hemoglobin, sickle cell anemia, thalasemia, phenylketonuria, alkaptonuria, albinism, etc. Electrolyte and acid balance: Acid-base balance, regulation of electrolyte and water balance, renin-angiotensin system in human body. Clinical analysis: Functional test of liver, kidney, thyroid, pancreas, tissue biopsy,
liquid biopsy, circulating nucleotides as molecular diagnosis.

UNIT-VI:

Immunological techniques: Immuno-electrophoresis, immune-precipitation, agglutination, RIA, ELISA, FACS, immune-fluorescence microscopy, Immuno-electron microscopy, Fluorescence In-situ hybridization (FISH), Chromatin immuno-precipitation. Statistics: Data collection and processing, Regression and Correlation, ANOVA analysis Probabilities; t-test, p-value; 2test.

UNIT-VII:

PHYSICAL EVIDENCE COLLECTION & PACKAGING OF EXHIBITS FROM CRIME SCENE: Physical evidence, types and importance in a criminal investigation, Protecting a scene of crime – various steps involved, contamination issues. Reconstructing of crime scene, Protection of Packaging & transportation Biological Evidences their documentation and Chain of Custody Legal and court procedure pertaining to expert testimony, admissibility of scientific evidence under 293 CrPC.

MICROSCOPY AND ITS APPLICATION : Basic principles and working of simple, Compound, Comparison, Phase-contrast, stereo-zoom, Polarizing, Fluorescence, confocal microscopy, Scanning electron and transmission electron microscope, colorimeter analysis and UV light source. Spectroscopy: Principle and significance of UV-Vis spectroscopy, Fluorescence spectroscopy, FRET, Luminescence, Circular Dichroism, Infra-Red spectroscopy, Raman spectroscopy, Nuclear Magnetic Resonance, X-ray diffraction, Mass
spectrometry

UNIT-VIII:

EXAMINATION OF BODY FLUIDS & THEIR STAINS: Introduction to various types of body fluids, Composition, Physical pattern and Identification of seminal stains: Occurence and significance. Species Determination. Age of semen stain. Detailed Laboratory examination of semen stain. Polymorphic Enzymes in semen and their significance. D.N.A.typing of semen sample. Examination of Saliva, Urine, Perspiration and other physiological fluids presumptive tests (U.V. test, Florence test, Spermine (Barberio) test,
Choline test, Acid phosphatase test) and confirmatory test including Azoospermic semen stain (p-30, Prostate-specific antigen or PSA, Microscopic examination), Morphological structure of spermatozoa of human and animals, Identification of lochial and menstrual blood stains by microscopic, biochemical and immuno-electrophoretic method, Identification and examination of other body fluids/stains–vaginal, saliva, urine, faeces, vomit etc., Secretor and non–secretor. Identification and examination of body tissues of human/animal.

IMMUNOLOGICAL TEST:
Presumptive & Confirmatory Tests for blood and origin. Application of immunological techniques in forensic serology Determination of species by precipitin test (diffusion method) and Gelelectrophoresis. Innate and Adaptive immunity, B cell /T cell –structure, development, diversity and recognition. Antigen and Antibodies –structure, types and function of antibody, monoclonal antibodies, antigen, hapten, adjuvants, antigen-antibody interaction and their  application. Blood groups- ABO, MN, Rh polymorphic blood groups, Application of ABO blood group in disputed paternity cases, polymorphic enzymes and polymorphic proteins in the reference of forensic serology. HLA antigen. Secretor and non secretor status. Blood grouping in biological fluids other than blood. Determination of ABO blood group by absorption inhibition, absorption elution and mixed agglutination method.

UNIT-IX:

FORENSIC GENETICS AND ROLE OF DNA FINGERPRINTING: History of DNA fingerprinting, utility of DNA fingerprinting in crime investigation in parentage dispute, wild life, veterinary and agriculture etc., Legal and Ethical issues. Collection, preservation and transport of samples viz, semen, saliva, hair, bone, flesh etc for DNA profiling, DNA methodology for isolation, typing, interpretation of results, STR analysis, polymerase chain reaction, types and it’s application, mitochondrial analysis, determination of sex & species and racial origin. Analytical techniques: Chromatography, Gel filtration, Ion exchange and affinity chromatography, Electrophoresis, SDS-PAGE, AGE, PFGE, Southern, Northern and Western blotting, ELISA, DNA foot printing, PCR, Asymmetric PCR, methylation-specific PCR, Nested PCR, Inverse PCR, reverse transcriptase  PCR, Real-time-PCR, Protein sequencing methods, DNA sequencing methods, Next Generation Sequencing RFLP maps, RAPD markers, AFLP markers, SNP analysis.

UNIT-X:

WILD LIFE FORENSICS:
Wild life, Importance of protected and endangered species of Animals. National and International scenario of wild life, Sanctuaries and National parks. Relevant provision of wild life and environmental act. Types of wildlife crimes, different methods of poaching of wildlife animals, Illegal Trade of wildlife material, Identification and examination of different kinds of wildlife crime exhibits. Examination of fabricated hides, ivory, nail etc. Identification of Wild life and domestic animal.

FORENSIC ENTOMOLOGY:
Introduction, History, Significance, Classification and Biology of insects and other arthropods, Life cycle and forensic application of insects, Importance of some bacteria, Micro Organism and Insects in Forensic Science. Determination of time since death (postmortem interval i.e. PMI) – Dipterans larval development & succession on carrion and its relationship to determine time of death, impact of ecological factors on insects developments, rearing insects & calculating PMI, identification of larval instars, determining whether the body has been moved, linking suspect to the scene, Forensic Entomo-toxicology- identification of drugs and toxins from the insects and larvae feeding on the body, collection and preservation of entomological evidence at a crime scene.

HISTOLOGICAL AND ANATOMICAL EXAMINATION OF SOME PLANTS YIELDING DRUG: Morphology and anatomy of plants, types of plants yielding drugs of abuse – opium, cannabis, coca, tobacco. Identification of plants of Cannabis sativa (Ganja & bhang), opium (Papaver somniferum), tobacco (Nicotiana tabacum) etc. in criminal cases.

Aspirants should refer to the official notice for a more detailed syllabus. Below is a direct link to the official notification for download.

Download Syllabus for Senior Scientific Officer (Serology Division) PDF

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How can I download RPSC Senior Scientific Officer Syllabus 2021?

The direct link to download RPSC Senior Scientific Officer Syllabus 2021 have provided above

How many vacancies in RPSC Recruitment 2021?

There are various vacancies allotted for these recruitment

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